Cellular regenerative therapy for acquired noncongenital musculoskeletal disorders
S. Afr. med. j. (Online)
;
109(8): 59-64, 2019. ilus
Artículo
en Inglés
| AIM
| ID: biblio-1271231
ABSTRACT
tem cells have an inherent capacity to facilitate regeneration; this has led to unprecedented growth in their experimental use in various clinical settings, particularly in patients with diseases with few alternative treatment options. However, their approved clinical use has to date been restricted largely to haematological diseases and epidermal transplantation to treat severe burns. After thorough searching of two databases, this review illuminates the role of stem cell therapy for treatment of musculoskeletal diseases. Research suggests that successful application of stem cells as regenerative mediators is in all likelihood dependent on the ability of endogenous tissue-resident reparative mediators to respond to paracrine signals provided by the applied stem cells. Therefore, an understanding of how the pathological environment influences this process is crucial for the ultimate success of stem cell therapies. The current review presents both the progress and limitations of stem cells as regenerative mediators in the context of musculoskeletal disorders
Buscar en Google
Índice:
AIM (África)
Asunto principal:
Sudáfrica
/
Células
/
Medicina Regenerativa
/
Fenómenos Fisiológicos Musculoesqueléticos
País/Región como asunto:
Africa
Idioma:
Inglés
Revista:
S. Afr. med. j. (Online)
Año:
2019
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS