Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population
Arch. endocrinol. metab. (Online)
;
65(3): 305-314, May-June 2021. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1285150
ABSTRACT
ABSTRACT Objective:
To study the association of SLC16A11 gene variants with obesity and metabolic markers in nondiabetic Chilean adults. Materials andmethods:
This cross-sectional study included 263 non-diabetic adults. The genotype of the rs75493593 polymorphism of SLC16A11 gene was performed by real-time PCR. It's association with adiposity markers (body weight, BMI, waist circumference and fat mass percentage), metabolic markers (glucose, insulin, HOMAIR, leptin, total cholesterol, LDLc, HDLc, triglycerides, ALT, GGT and hsCRP) and blood pressure was analyzed by linear regression.Results:
The minor allele (T) of the SLC16A11 gene (rs75493593) has a frequency of 29.7% among Chileans. Risk genotypes (GT and TT) were associated with a significant 1.49 mU/l increase in plasmatic insulin for each copy of the minor allele (95% CI 0.12, 2.87, p < 0.05). This association remained significant after adjusting for socio-demographic variables, physical activity and smoking (1.36 mU/l, 95% CI 0.16, 2.58 p < 0.05), but was lost when BMI was included as a confounding factor. Higher BMI was also significantly associated with polymorphic genotypes in SLC16A11, independent of socio-demographic variables.Conclusion:
The minor allele of the SLC16A11 gene (T) is highly prevalent among Chileans and is associated with increased insulin and BMI in nondiabetic individuals. These findings suggest that the genetic variant in SLC16A11 is not only associated with type 2 diabetes as previously shown in Mexicans, but is also related to early metabolic alterations in healthy subjects that may lead to type 2 diabetes.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Índice de Masa Corporal
/
Transportadores de Ácidos Monocarboxílicos
/
Insulina
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Adulto
/
Humanos
País/Región como asunto:
America del Sur
/
Chile
Idioma:
Inglés
Revista:
Arch. endocrinol. metab. (Online)
Asunto de la revista:
Endocrinologia
/
Metabolismo
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Chile
/
Reino Unido
Institución/País de afiliación:
Universidad Austral de Chile/CL
/
Universidad Católica de la Santísima Concepción/CL
/
Universidad Santo Tomas/CL
/
Universidad de Chile/CL
/
Universidad de Concepción/CL
/
University of Glasgow/GB
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