Perspectives of bilateral thoracic sympathectomy for treatment of heart failure
Clinics
;
76: e3248, 2021. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1286075
ABSTRACT
Surgical neuromodulation therapies are still considered a last resort when standard therapies have failed for patients with progressive heart failure (HF). Although a number of experimental studies have provided robust evidence of its effectiveness, the lack of strong clinical evidence discourages practitioners. Thoracic unilateral sympathectomy has been extensively studied and has failed to show significant clinical improvement in HF patients. Most recently, bilateral sympathectomy effect was associated with a high degree of success in HF models, opening the perspective to be investigated in randomized controlled clinical trials. In addition, a series of clinical trials showed that bilateral sympathectomy was associated with a decreased risk of sudden death, which is an important outcome in patients with HF. These aspects indicates that bilateral sympathectomy could be an important alternative in the treatment of HF wherein pharmacological treatment barely reaches the target dose.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Procedimientos Quirúrgicos Torácicos
/
Insuficiencia Cardíaca
/
Hiperhidrosis
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Humanos
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Suecia
Institución/País de afiliación:
Karolinska Institutet/SE
/
Universidade de Sao Paulo/BR
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