Relationship of the low-density lipoprotein (LDL)/high-density lipoprotein (HDL) index with antioxidant enzymes and with the oxLDL/HDL index
Gac. méd. Méx
;
155(5): 453-457, Sep.-Oct. 2019. tab
Artículo
en Inglés
| LILACS
| ID: biblio-1286542
ABSTRACT
Introduction:
The low-density lipoprotein (LDL)/high-density lipoprotein (HDL) index is a predictive factor for atherosclerosis, which is associated with oxidative modifications.Objective:
To assess the association of the index with oxidative stress markers.Methods:
444 subjects were included and were clinically, anthropometrically and biochemically characterized; superoxide dismutase, glutathione peroxidase 3 (GPx3), magnesium and oxidized LDL (oxLDL) index (oxLDL/HDL) were quantified.Results:
A decrease of 1.014 units in the LDL/HDL index was associated with a superoxide dismutase increase of 1 unit/mL (p = 0.030), while a decrease of 0.023 units was associated with a GPx3 increase of 1 nmol/min/mL (p < 0.0005). An increase of one unit in the index was associated with an increase of 0.831 in the oxLDL/HDL index (p < 0.05). After controlling for the effect of gender, age, smoking, obesity and insulin resistance, a reduction of 0.001 per index unit was associated with an increase of 1 µg/g of magnesium in the nails (p = 0.020).Conclusions:
The LDL/HDL index shows an inverse relationship with the antioxidant status and a direct relationship with oxidation status, regardless of other cardiovascular and oxidative stress risk factors.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Superóxido Dismutasa
/
Estrés Oxidativo
/
Glutatión Peroxidasa
/
Lipoproteínas HDL
/
Lipoproteínas LDL
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Gac. méd. Méx
Asunto de la revista:
Medicina
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
México
Institución/País de afiliación:
Benemérita Universidad Autónoma de Puebla/MX
/
Instituto Mexicano del Seguro Social/MX
/
Instituto Politécnico Nacional/MX
/
Universidad Autónoma del Estado de Morelos/MX
Similares
MEDLINE
...
LILACS
LIS