Prevalence and diagnostic accuracy of microcephaly in a pediatric cohort in Brazil: a retrospective cross-sectional study
J. pediatr. (Rio J.)
;
97(4): 433-439, July-Aug. 2021. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1287047
ABSTRACT
Abstract Objective We sought to describe the prevalence of microcephaly and to compare the different cutoff points established by the Brazilian Ministry of Health at various times during a Zika virus epidemic. As a secondary aim, we investigated the possible etiology of the microcephaly. Method This retrospective study utilized newborn participants in the Zika Cohort Study Jundiaí. Newborns from the Zika Cohort Study Jundiaí with an accurate gestational age determination and complete anthropometric data were analyzed, and microcephaly was diagnosed according to the INTERGROWTH-21st curve. At delivery, fluids were tested for specific antibodies and for viruses. Brain images were evaluated for microcephaly. Receiver Operating Characteristic curves were plotted to define the accuracy of different cutoff points for microcephaly diagnosis. Results Of 462 eligible newborns, 19 (4.1%) were positive for microcephaly. Cutoff points corresponding to the curves of the World Health Organization yielded the best sensitivity and specificity. Three of the microcephaly cases (15.8%) were positive for Zika virus infections; nine (47.4%) had intrauterine growth restriction; one had intrauterine growth restriction and was exposed to Zika virus; three had a genetic syndrome (15.8%); and three had causes that had not been determined (15.8%). Conclusions Microcephaly prevalence was 4.1% in this study. Cutoff values determined by the World Health Organization had the highest sensitivity and specificity in relation to the standard IG curve. The main reason for microcephaly was intrauterine growth restriction. All possible causes of microcephaly must be investigated to allow the best development of an affected baby.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Complicaciones Infecciosas del Embarazo
/
Virus Zika
/
Infección por el Virus Zika
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Lactante
/
Embarazo
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
J. pediatr. (Rio J.)
Asunto de la revista:
Pediatría
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
España
Institución/País de afiliación:
Faculdade de Medicina de Jundiaí/BR
/
Hospital Universitari Sant Joan de Déu/ES
/
Hospital Universitari Vall dHebron/ES
/
Universidade de São Paulo/BR
/
University of Barcelona/ES
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