Mechanism of action of glycyrrhizin against Plasmodium falciparum
Mem. Inst. Oswaldo Cruz
;
116: e210084, 2021. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1287344
ABSTRACT
Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity (i) drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition of the detoxifying enzyme glyoxalase 1 (GLO-1) considered as an important drug target for malaria. Our analysis shed light on the mechanism of action of GLR against P. falciparum.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Triterpenos
/
Glycyrrhiza
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Francia
Institución/País de afiliación:
Fundação Oswaldo Cruz-Fiocruz/BR
/
OncoWitan/FR
/
University of Lille/FR
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