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Fasting insulin and alanine amino transferase, but not FGF21, were independent parameters related with irisin increment after intensive aerobic exercising
Torre-Saldaña, Viridiana A. de la; Gómez-Sámano, Miguel Ángel; Gómez-Pérez, Francisco Javier; Rosas-Saucedo, Juan; León-Suárez, Andrés; Grajales-Gómez, Mariana; Oseguera-Moguel, Jorge; Vega-Beyhart, Arturo; Cuevas-Ramos, Daniel.
  • Torre-Saldaña, Viridiana A. de la; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Endocrinology and Metabolism. Mexico City. MX
  • Gómez-Sámano, Miguel Ángel; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Endocrinology and Metabolism. Mexico City. MX
  • Gómez-Pérez, Francisco Javier; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Endocrinology and Metabolism. Mexico City. MX
  • Rosas-Saucedo, Juan; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Endocrinology and Metabolism. Mexico City. MX
  • León-Suárez, Andrés; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Endocrinology and Metabolism. Mexico City. MX
  • Grajales-Gómez, Mariana; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Endocrinology and Metabolism. Mexico City. MX
  • Oseguera-Moguel, Jorge; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Cardiology. Mexico City. MX
  • Vega-Beyhart, Arturo; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Endocrinology and Metabolism. Mexico City. MX
  • Cuevas-Ramos, Daniel; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Endocrinology and Metabolism. Mexico City. MX
Rev. invest. clín ; 71(2): 133-140, Mar.-Apr. 2019. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1289679
ABSTRACT
Abstract Background Irisin is a protein cleaved from fibronectin type III domain-containing protein 5 and has been implicated in the beneficial effects of exercise. However, it is unknown which factors contribute to irisin increment after intensive exercising in humans. This study aimed to assess independent factors related with serum irisin after 2 weeks of supervised physical activity in young sedentary healthy women. Design and Methods We developed a comparative, interventional, longitudinal, and prospective study at a third-level specialty health center. Between March 2010 and August 2011, 82 sedentary young adult women, without chronic diseases or regular medical treatments, were recruited. A total of 38 women fulfilled selection criteria, and irisin concentrations were quantified before and after the intervention. Independent factors related with irisin increment were evaluated according to mild to moderate and vigorous intensity of physical activity. A supervised treadmill exercise test following the Bruce’s protocol was conducted from Monday to Friday during 2 weeks. In addition, anthropometric measurements were taken, and fibroblast growth factor 21 (FGF21), glucose, insulin, and liver transaminases were measured. Results Intensity of exercising was directly related to irisin (p = 0.02) and FGF21 (p = 0.01) serum levels. However, an independent and significant relationship between FGF21 and irisin was not confirmed. A novel association was found between alanine aminotransferase (ALT) and irisin, showing a positive and significant correlation (r = 0.37, p = 0.02). The association was particularly strong with higher intensity of aerobic exercising (r = 0.64, p = 0.01). Linear regression model adjusted for glucose and body mass index confirmed an independent association between ALT and irisin and also between insulin and irisin (adjusted R² = 0.12, p = 0.04). Such association increased after grouping in moderate to vigorous physical activity intensity (adjusted R² = 0.46, F = 4.7, p = 0.03). Conclusions Serum irisin and FGF21 levels significantly increased after 2 weeks of supervised physical activity. However, only fasting insulin and ALT, but not FGF21, were independent parameters explaining irisin increment, mainly after moderate to vigorous exercising.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Ejercicio Físico / Fibronectinas / Alanina Transaminasa / Factores de Crecimiento de Fibroblastos / Insulina Tipo de estudio: Guía de Práctica Clínica / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adulto / Femenino / Humanos Idioma: Inglés Revista: Rev. invest. clín Asunto de la revista: Medicina Año: 2019 Tipo del documento: Artículo País de afiliación: México Institución/País de afiliación: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Ejercicio Físico / Fibronectinas / Alanina Transaminasa / Factores de Crecimiento de Fibroblastos / Insulina Tipo de estudio: Guía de Práctica Clínica / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adulto / Femenino / Humanos Idioma: Inglés Revista: Rev. invest. clín Asunto de la revista: Medicina Año: 2019 Tipo del documento: Artículo País de afiliación: México Institución/País de afiliación: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX