Exploratory analysis of polygenic risk scores for psychiatric disorders: Applied to dual diagnosis
Rev. invest. clín
;
71(5): 321-329, Sep.-Oct. 2019. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1289702
ABSTRACT
Background Concurrence of substance use disorders (SUDs) is high in individuals with psychiatric illnesses; more importantly, individuals with both disorders (dual diagnosis) have more severe symptoms. Psychiatric disorders have been proposed to share a genetic susceptibility with SUDs. To explore this shared genetic susceptibility, we analyzed whether any of the polygenic risk scores (PRSs) for psychiatric disorders could be associated to dual diagnosis in patients with schizophrenia (SCZ) or bipolar disorder (BD). Methods We included 192 individuals of Mexican ancestry 72 with SCZ, 53 with BD, and 67 unrelated controls without psychiatric disorders. We derived calculations of PRS for autism spectrum disorders, attention-deficit/hyperactive disorder, BD, major depression, and SCZ using summary genome-wide association statistics previously published. Results We found that dual diagnosis had a shared genetic susceptibility with major depressive disorder (MDD) and SCZ; furthermore, in individuals with BD, dual diagnosis could be predicted by PRS for MDD. Conclusions Our results reinforce the notion that individuals with dual diagnosis have a higher genetic susceptibility to develop both disorders. However, analyses of larger sample sizes are required to further clarify how to predict risks through PRS within different populations.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Esquizofrenia
/
Trastorno Bipolar
/
Trastornos Relacionados con Sustancias
/
Trastornos Mentales
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
México
Idioma:
Inglés
Revista:
Rev. invest. clín
Asunto de la revista:
Medicina
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
México
/
Estados Unidos
Institución/País de afiliación:
Grupo de Estudios Médicos y Familiares Carracci/MX
/
Instituto Nacional de Cancerología/MX
/
Instituto Nacional de Medicina Genómica/MX
/
Texas Tech University/US
/
Universidad Autónoma de Nuevo León/MX
/
Universidad Juárez Autónoma de Tabasco/MX
/
Universidad Nacional Autónoma de México/MX
Similares
MEDLINE
...
LILACS
LIS