Prognostic significance of the mad1l1 1673 g:a polymorphism in ovarian adenocarcinomas
Rev. invest. clín
; 72(6): 372-379, Nov.-Dec. 2020. tab, graf
Article
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| ID: biblio-1289732
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BR1.1
ABSTRACT
Abstract Background:
Ovarian cancer is the most lethal gynecologic cancer. Although most patients respond adequately to the first-line therapy, up to 85% experience a recurrence of disease, which carries a poor prognosis. Mitotic arrest deficiency 1 is a protein that helps in the assembly of the mitotic spindle assembly checkpoint by preventing anaphase until all chromatids are properly aligned. A single-nucleotide polymorphism in the MAD1L1 gene is prevalent in patients with advanced epithelial ovarian cancer and alters the way in which it responds to chemotherapy.Objective:
The objective of the study was to study the relationship between the rs1801368 polymorphism of MAD1L1 and prognosis of ovarian adenocarcinoma.Methods:
A total of 118 patients in whom the MAD1L1 gene was sequenced were analyzed using descriptive and comparative statistics.Results:
Patients carrying the wild-type genotype had a higher distribution of early-stage disease. Having a MAD1L1 polymorphic allele increased the risk of being non-sensitive to chemotherapy. The median disease-free survival for patients with the wild-type MAD1L1 was 46.93 months, compared to 10.4 months for patients with at least one polymorphic allele.Conclusions:
The rs1801368 polymorphism of MAD1L1 gene worsens prognosis in patients with ovarian adenocarcinoma. Traditional therapy for ovarian cancer might not be optimal in patients carrying this polymorphism.Palabras clave
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Índice:
LILACS
Asunto principal:
Neoplasias Ováricas
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Adenocarcinoma
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Proteínas de Ciclo Celular
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Polimorfismo de Nucleótido Simple
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
Idioma:
En
Revista:
Rev. invest. clín
Asunto de la revista:
MEDICINA
Año:
2020
Tipo del documento:
Article