Your browser doesn't support javascript.
loading
Triple-negative breast cancer cells respond to T cells severely at the alternative splicing layer
Zhao, Lina; Yang, Xi; Feng, Chun; Wang, Yue; Wang, Qing; Pei, Jiahong; Wu, Jinting; Li, Shuaiying; Zhang, Honglei; Cao, Xianbao.
  • Zhao, Lina; First People's Hospital of Yunnan Province. Department of Otolaryngology. Kunming. CN
  • Yang, Xi; The First Affiliated Hospital of Kunming Medical University. The Second Department of Otolaryngology Head and Neck Surgery. Kunming. CN
  • Feng, Chun; First People's Hospital of Yunnan Province. Department of Otolaryngology. Kunming. CN
  • Wang, Yue; Third Affiliated Hospital of Kunming Medical University. Department of Breast Cancer. Kunming. CN
  • Wang, Qing; Qujing First People's Hospital. Department of Oncology. Qujing. CN
  • Pei, Jiahong; First People's Hospital of Yunnan Province. Department of Otolaryngology. Kunming. CN
  • Wu, Jinting; Yunnan University of Chinese Medicine. Kunming. CN
  • Li, Shuaiying; Yunnan University of Chinese Medicine. Kunming. CN
  • Zhang, Honglei; Chinese Academy of Sciences. Kunming Institute of Zoology. State Key Laboratory of Genetic Resources and Evolution. Kunming. CN
  • Cao, Xianbao; First People's Hospital of Yunnan Province. Department of Otolaryngology. Kunming. CN
Electron. j. biotechnol ; 50: 59-67, Mar. 2021. ilus, graf, tab
Artículo en Inglés | LILACS | ID: biblio-1292412
ABSTRACT

BACKGROUND:

Cross talk of tumor­immune cells at the gene expression level has been an area of intense research. However, it is largely unknown at the alternative splicing level which has been found to play important roles in the tumor­immune microenvironment.

RESULTS:

Here, we re-exploited one transcriptomic dataset to gain insight into tumor­immune interactions from the point of AS level. Our results showed that the AS profiles of triple-negative breast cancer cells co-cultured with activated T cells were significantly changed but not Estrogen receptor positive cells. We further suggested that the alteration in AS profiles in triple-negative breast cancer cells was largely caused by activated T cells rather than paracrine factors from activated T cells. Biological pathway analyses showed that translation initiation and tRNA aminoacylation pathways were most disturbed with T cell treatment. We also established an approach largely based on the AS factor­AS events associations and identified LSM7, an alternative splicing factor, may be responsible for the major altered events.

CONCLUSIONS:

Our study reveals the notable differences of response to T cells among breast cancer types which may facilitate the development or improvement of tumor immunotherapy.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Linfocitos T / Neoplasias de la Mama Triple Negativas Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Electron. j. biotechnol Asunto de la revista: Biotecnologia Año: 2021 Tipo del documento: Artículo País de afiliación: China Institución/País de afiliación: Chinese Academy of Sciences/CN / First People's Hospital of Yunnan Province/CN / Qujing First People's Hospital/CN / The First Affiliated Hospital of Kunming Medical University/CN / Third Affiliated Hospital of Kunming Medical University/CN / Yunnan University of Chinese Medicine/CN

Similares

MEDLINE

...
LILACS

LIS


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Linfocitos T / Neoplasias de la Mama Triple Negativas Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Electron. j. biotechnol Asunto de la revista: Biotecnologia Año: 2021 Tipo del documento: Artículo País de afiliación: China Institución/País de afiliación: Chinese Academy of Sciences/CN / First People's Hospital of Yunnan Province/CN / Qujing First People's Hospital/CN / The First Affiliated Hospital of Kunming Medical University/CN / Third Affiliated Hospital of Kunming Medical University/CN / Yunnan University of Chinese Medicine/CN