Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Arch. endocrinol. metab. (Online)
;
65(4): 468-478, July-Aug. 2021. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1339110
ABSTRACT
ABSTRACT Objective:
To evaluate incidence of subclinical and overt hyperthyroidism and hypothyroidism. Subjects andmethods:
The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study of 15,105 civil servants, examined at baseline and over a 4-year follow-up. This analysis included 9,705 participants with normal thyroid function at baseline, follow-up information about thyroid function and with no report of using drugs that may interfere in the thyroid function. Thyroid function was defined by TSH/FT4 levels or routine use of thyroid hormones/anti-thyroid medications. Annual and cumulative (over 4-year) incidence rates were presented as percentages (95% Confidence Intervals).Results:
The incidence of all overt and subclinical thyroid disease was 6.7% (1.73%/year) 0.19% for overt hyperthyroidism (0.048%/year), 0.54% for subclinical hyperthyroidism (0.14%/year), 1.98% for overt hypothyroidism (0.51%/year), and 3.99% for subclinical hypothyroidism (1.03%/year). The incidence of all thyroid diseases was higher in women, when compared to men, with a low womenmen ratio (1.36). For Blacks the highest incidence was for overt hyperthyroidism, while for Whites, the highest incidence was for overt hypothyroidism. However, the highest incidence of overt hyperthyroidism was detected in Asian descendants. The presence of antithyroperoxidase antibodies at baseline was associated with higher incidence of overt thyroid diseases.Conclusion:
These results showed a high incidence of hypothyroidism, which is compatible with a country with a more-than-adequate iodine intake. The low womenmen ratio of the incidence of thyroid dysfunction highlights the importance of the diagnosis of thyroid diseases among men in Brazil.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Enfermedades de la Tiroides
/
Hipertiroidismo
Tipo de estudio:
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Arch. endocrinol. metab. (Online)
Asunto de la revista:
Endocrinologia
/
Metabolismo
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Faculdade de Medicina de Marília/BR
/
Fundação Oswaldo Cruz - Fiocruz/BR
/
Fundação Oswaldo Cruz/BR
/
Universidade Federal da Bahia/BR
/
Universidade Federal de Minas Gerais/BR
/
Universidade Federal de São Paulo/BR
/
Universidade Federal do Espírito Santo/BR
/
Universidade Federal do Rio Grande do Sul/BR
/
Universidade de São Paulo/BR
Similares
MEDLINE
...
LILACS
LIS