Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes
Braz. J. Pharm. Sci. (Online)
;
57: e18997, 2021. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1345455
ABSTRACT
In the present study a series of 34 synthetic ligustrazine-containing α, ß-Unsaturated carbonyl-based compounds and oximes, recognized as anticancer compounds were assessed against protozoa of the Trypanosoma and Leishmania species. Ligustrazine, chemically known as tetramethylpyrazine (TMP), was selected as the core moiety for the synthesis of α, ß-Unsaturated carbonyl-based compounds and these compounds were selected as precursors for the synthesis of new oximes. Some derivates, including 5f and 6i, showed multiple activities against all tested strains. In particular compounds 5f and 8o are the most potent and they are, therefore, potential candidates for trypanosomiasis and leishmaniasis
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Oximas
/
Ciclohexanonas
Idioma:
Inglés
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
/
Teraputica
/
Toxicologia
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Arabia Saudita
/
Reino Unido
Institución/País de afiliación:
Institute of Infection, Immunity and Inflammation/GB
/
Jouf University/SA
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