Diagnostic and prognostic value of serum miR-9-5p and miR-128-3p levels in early-stage acute ischemic stroke
Clinics
;
76: e2958, 2021. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1345819
ABSTRACT
OBJECTIVES:
To investigate the clinical utility of serum microRNA levels (miR-9-5p and miR-128-3p) in the diagnosis and prognosis of early-stage acute ischemic stroke (AIS).METHODS:
We compared the differences in serum miR-9-5p and miR-128-3p levels between patients with AIS and healthy individuals (controls). The serum levels of miR-9-5p and miR-128-3p were quantified using quantitative real-time PCR, and the association of each miRNA with AIS was determined using receiver operator characteristic curve analysis. The predictive value of these indices in the diagnosis of early-stage AIS was evaluated in conjunction with that of computed tomography findings and neuron-specific enolase levels. The prognosis of patients with AIS was evaluated three months after their discharge from hospital using the modified Rankin scale, which classifies the prognosis as either favorable or poor. Logistic regression analysis was used to analyze the correlation between miR-9-5p and miR-128-3p levels and patient prognosis.RESULTS:
The serum levels of miR-9-5p and miR-128-3p were upregulated in patients with AIS relative to those in healthy individuals. A pronounced correlation was identified between serum miR-9-5p and miR-128-3p levels and patient prognosis, with high levels of both miRNAs being associated with poor patient outcomes.CONCLUSION:
Assessment of serum miR-9-5p and miR-128-3p levels is important for the early diagnosis and prognosis of AIS.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Isquemia Encefálica
/
MicroARNs
/
Accidente Cerebrovascular Isquémico
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Beijing Rehabilitation Hospital of Capital Medical University/CN
/
Binzhou Hospital of Traditional Chinese Medicine/CN
/
Gaoqing County Peoples Hospital/CN
/
Gucheng County Hospital of Hebei Province/CN
/
Yantai Municipal Laiyang Central Hospital/CN
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