Inflammation: improving understanding to prevent or ameliorate kidney diseases
J. venom. anim. toxins incl. trop. dis
;
27: e20200162, 2021. tab, graf
Artículo
en Inglés
| LILACS, VETINDEX
| ID: biblio-1346434
ABSTRACT
Inflammatory processes are believed to play an important role in immune response to maintain tissue homeostasis by activating cellular signaling pathways and releasing inflammatory mediators in the injured tissue. Although acute inflammation can be considered protective, an uncontrolled inflammation may evolve to tissue damage, leading to chronic inflammatory diseases. Inflammation can be considered the major factor involved in the pathological progression of acute and chronic kidney diseases. Functional characteristics of this organ increase its vulnerability to developing various forms of injuries, including acute kidney injury (AKI) and chronic kidney disease (CKD). In view of translational research, several discoveries should be considered regarding the pathogenesis of the inflammatory process, which results in the validation of biomarkers for early detection of kidney diseases. Biomarkers enable the identification of proinflammatory mediators in kidney affections, based on laboratory research applied to clinical practice. Some inflammatory molecules can be useful biomarkers for the detection and diagnosis of kidney diseases, such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and interleukin 18.(AU)
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Biomarcadores
/
Lesión Renal Aguda
/
Inflamación
/
Enfermedades Renales
Tipo de estudio:
Estudio pronóstico
/
Estudio de tamizaje
Idioma:
Inglés
Revista:
J. venom. anim. toxins incl. trop. dis
Año:
2021
Tipo del documento:
Artículo
Institución/País de afiliación:
University of São Paulo/BR
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