Exploring the expression profile of vitamin D receptor and its related long non-coding RNAs in patients with acute lymphoblastic leukemia
Rev. Assoc. Med. Bras. (1992)
;
67(8): 1113-1117, Aug. 2021. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1346981
ABSTRACT
SUMMARY OBJECTIVE: Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer. Previous studies have indicated the involvement of vitamin D receptor (VDR) and related long noncoding RNAs (lncRNAs) signaling in the pathophysiology of several cancers. However, their contribution to ALL remains to be elucidated. METHODS: In this case-control study, 30 patients with newly diagnosed ALL and 30 age- and sex-matched healthy children were selected. Then, the level of 25(OH) vitamin D and the expression of VDR and four VDR-related lncRNAs were assessed. RESULTS: No significant difference in serum 25(OH) vitamin D was observed between patients with ALL (20.42±6.5 ng/mL) and healthy subjects (25.45±11 ng/mL). In addition, the expression of MALAT-1, HOTAIR, and P-21 was not statistically significant between the two groups. However, a significant reduction in VDR and H19 expression was observed in patients with ALL (p<0.05). CONCLUSIONS: 25(OH) vitamin D insufficiency was evident in both groups. VDR and H19 signaling might be contributed to the pathogenesis of ALL, which needs further investigations.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Receptores de Calcitriol
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
ARN Largo no Codificante
Tipo de estudio:
Estudio observacional
Límite:
Niño
/
Humanos
Idioma:
Inglés
Revista:
Rev. Assoc. Med. Bras. (1992)
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Irán
Institución/País de afiliación:
Department of Clinical Biochemistry, Faculty of Medicine/IR
/
Department of Hematology and Blood Banking/IR
/
Student Research Committee/IR
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