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Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease
Longo, Aline; Veiga, Gabriel Barreto; Cousen, Maria Isabel Schiavon; Karpinski, Caroline; Schneider, Augusto; Weber, Bernardete; Bertoldi, Eduardo Gehling; Borges, Lucia Rota; Bertacco, Renata Torres Abib.
  • Longo, Aline; Universidade Federal de Pelotas. Faculdade de Nutrição. Pelotas. BR
  • Veiga, Gabriel Barreto; Universidade Federal de Pelotas. Faculdade de Nutrição. Pelotas. BR
  • Cousen, Maria Isabel Schiavon; Universidade Federal de Pelotas. Faculdade de Nutrição. Pelotas. BR
  • Karpinski, Caroline; Universidade Federal de Pelotas. Faculdade de Nutrição. Pelotas. BR
  • Schneider, Augusto; Universidade Federal de Pelotas. Faculdade de Nutrição. Pelotas. BR
  • Weber, Bernardete; Instituto de Pesquisa - Hospital do Coração. São Paulo. BR
  • Bertoldi, Eduardo Gehling; Universidade Federal de Pelotas. Faculdade de Medicina. Pelotas. BR
  • Borges, Lucia Rota; Universidade Federal de Pelotas. Faculdade de Nutrição. Pelotas. BR
  • Bertacco, Renata Torres Abib; Universidade Federal de Pelotas. Faculdade de Nutrição. Pelotas. BR
Arch. endocrinol. metab. (Online) ; 65(6): 676-683, Nov.-Dec. 2021. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1349986
ABSTRACT
ABSTRACT

Objectives:

Paraoxonase 1 (PON1) is an enzyme that has antioxidant potential, which confers a protective effect against the atherosclerotic process. However, studies associating genetics, dietary patterns and PON1 activity in individuals with cardiovascular disease (CVD) are scarce. Thus, the aim of the current study was to evaluate the influence of dietary factors on serum PON1 in CVD patients. Subjects and

methods:

Cross-sectional, sub-study of the BALANCE Program Trial. All patients aged 45 years or older and had evidence of established atherosclerotic disease in the preceding 10 years. Body weight, height, waist circumference, blood pressure, lipid profile and fasting glucose were collected. Food intake was assessed with 24-h dietary recall. Data was analyzed using SAS University Edition and a P value ≤ 0.05 was considered statistically significant. Sample was divided into three groups, according to the PON1 T(-107)C genotype (CC, CT and TT) and serum PON1 activity (Low, Medium, High).

Results:

There were no genotype differences for major factors. However, the systolic blood pressure was lower for CT individuals (p<0.05). Intake of cholesterol, saturated fatty acids (SFA) and monounsaturated fatty acids (MUFAS) was higher in patients with lower PON1 activity. Lipid ingestion tended to be higher in patients with lower PON1 activity (p=0.08). In the multivariate logistic regression model, SFA intake (P=0.03), genotype (P=0.09), gender (P=0.04), age (P=0.07) and carbohydrate intake (P=0.16) contributed the most to the serum PON1 activity.

Conclusion:

Based on these findings, nutritional guidance for these patients becomes essential, since dietary components interact with serum PON1 activity more than genotype.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Enfermedades Cardiovasculares / Arildialquilfosfatasa Tipo de estudio: Estudio observacional / Estudio de prevalencia / Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: Endocrinologia / Metabolismo Año: 2021 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Instituto de Pesquisa - Hospital do Coração/BR / Universidade Federal de Pelotas/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Enfermedades Cardiovasculares / Arildialquilfosfatasa Tipo de estudio: Estudio observacional / Estudio de prevalencia / Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: Endocrinologia / Metabolismo Año: 2021 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Instituto de Pesquisa - Hospital do Coração/BR / Universidade Federal de Pelotas/BR