Pregnancy has no significant impact on the prognosis of differentiated thyroid cancer
Arch. endocrinol. metab. (Online)
;
65(6): 768-777, Nov.-Dec. 2021. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1349988
ABSTRACT
ABSTRACT Objective:
To evaluate the impact of pregnancy on differentiated thyroid carcinomas (DTC) behavior Subjects andmethods:
Retrospective study of patients diagnosed with DTC before or during pregnancy and treated with standard therapy. In women diagnosed with DTC before pregnancy, we evaluated the occurrence of progression according to categories of response to therapy based on imaging and non-stimulated thyroglobulin (TG) levels.Results:
Of 96 analyzed patients, 76 became pregnant after DTC treatment and 20 were diagnosed with DTC during pregnancy. Among women who became pregnant after a DTC diagnosis, no difference was observed regarding response to therapy before and after pregnancy. Disease progression after pregnancy was documented in six of these patients, while seven of them presented progression before pregnancy but were only treated after delivery. Patients with DTC diagnosed during pregnancy had a higher rate of distant metastases at diagnosis (30%) compared with the patients who became pregnant after DTC diagnosis (9.2%, p = 0.01).Conclusion:
Pregnancy had no impact on the natural course of DTC. Disease progression after pregnancy was limited and probably related to more aggressive disease and higher risk stratification at diagnosis. Still, mild disease progression may have occurred asymptomatically in some patients.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Tiroidectomía
/
Neoplasias de la Tiroides
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Embarazo
Idioma:
Inglés
Revista:
Arch. endocrinol. metab. (Online)
Asunto de la revista:
Endocrinologia
/
Metabolismo
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Instituto Nacional do Câncer/BR
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