Association of coronary calcification with prognosis of Covid-19 patients without known heart disease
Braz. j. med. biol. res
; 54(12): 11681, 2021. graf, ilus, tab
Article
en En
| LILACS, CONASS, SES-SP, SESSP-IDPCPROD, SES-SP
| ID: biblio-1350328
Biblioteca responsable:
BR79.1
ABSTRACT
Risk factors that determine the severity of Covid-19 have not been fully elucidated. The aim of this study was to evaluate the role of coronary artery calcification (CAC) as a risk factor for death or mechanical ventilation (MV) of patients without known heart disease infected with Covid-19. We analyzed 283 consecutive in-patients with acute respiratory symptoms with chest computed tomography (chest-CT), without previous heart disease, and criteria for Covid-19 (RT-PCR positive and/or typical clinical and chest-CT findings). CAC was classified by the number of coronary segments affected as absent (0), mild (1-3), and severe calcification (more than 3). The association between CAC, CAC severity, and death or MV due to severe respiratory failure was assessed by logistic regression. The mean age was 58.7±15.7 years and 54.1% were men. Patients with CAC were older, more likely to have hypertension, and less likely to be obese. CAC was present in 75 patients (26.5%), of which 42 had a mild calcification and 33 had severe calcification, and was associated with death (OR=2.35, 95%CI 1.01-5.48) or MV (OR=2.72, 95%CI 1.20-6.20) adjusted for multiple confounders, with significant and increased odds ratio for the severe form of CAC (death OR=3.70, 95%CI 1.20-11.42; MV OR=3.30, 95%CI 1.09-9.95). We concluded that CAC was an independent risk factor for death or MV in Covid-19 patients without previous heart disease, particularly for those with severe calcification. CAC can be easily visualized on common chest-CT, widely used in evaluation of moderate to severe Covid-19.
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Texto completo:
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Índice:
LILACS
Asunto principal:
Factores de Riesgo de Enfermedad Cardiaca
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2021
Tipo del documento:
Article