The effectiveness of dexamethasone on the prognosis of dialysis patients with severe COVID-19
Rev. Assoc. Med. Bras. (1992)
;
67(9): 1299-1304, Sept. 2021. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1351491
ABSTRACT
SUMMARY OBJECTIVE:
This study aimed to investigate the effectiveness of dexamethasone in dialysis patients with COVID-19 and whether it predicts mortality.METHODS:
This is a comparative cross-sectional study of 113 consecutive patients with COVID-19 with severe pneumonia signs. The patients were divided into two groups according to the use of dexamethasone treatment group 1 (n=45) included patients who were treated with dexamethasone and group 2 (n=68) who did not receive dexamethasone.RESULTS:
The mean age of both groups was 67.0±10.6 and 67.2±13.0 years, respectively (p=0.947). With respect to demographic and laboratory findings, there were no significant differences between the two groups (p>0.05). The hospitalization time of patients in group 1 was longer than that in group 2 (11 [7-17] days vs. 8 [5.3-14] days, p=0.093]. The 28-day survival rate was 54.2% in the group receiving dexamethasone treatment and 79.5% in the group not receiving dexamethasone treatment (p=0.440).CONCLUSION:
Dexamethasone did not reduce mortality rates and the requirement for intensive care unit in dialysis patients with COVID-19. Larger prospective randomized clinical trials are required to associate personalized medicine with the corticosteroid treatment to select suitable patients who are more likely to show a benefit.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
COVID-19
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Rev. Assoc. Med. Bras. (1992)
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Sakarya University Faculty of Medicine/TR
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