Impact of quality of response on survival outcomes among multiple myeloma patients treated with novel agents - a retrospective analysis
São Paulo med. j
;
140(2): 222-228, Jan.-Feb. 2022. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1366039
ABSTRACT
Abstract BACKGROUND:
In this era of target therapies, novel data on the correlation between response endpoints and survival outcomes in multiple myeloma have arisen.OBJECTIVE:
To determine the impact of quality of response on clinical outcomes, using first-line treatment, and identify risk factors influencing progression-free survival (PFS) and overall survival (OS) among myeloma patients. DESIGN ANDSETTING:
Retrospective analysis on myeloma patients who were treated at the Clinic of Hematology and Clinical Immunology, University Clinical Centre, Niš, Serbia, over a four-year period.METHODS:
A total of 108 newly diagnosed patients who received first-line therapy consisting of conventional chemotherapy or novel agent-based regimens were included in this analysis.RESULTS:
The quality of response to first-line therapy for the whole cohort was classified as follows complete response (CR) in 19%; very good partial response (VGPR) in 23%; partial response (PR) in 38%; and less than PR for the remaining patients. After a median follow-up of 25.4 months, the three-year PFS and OS for the entire study population were 47% and 70%, respectively. Achievement of CR was the main factor associated with significantly prolonged PFS and OS, in comparison with patients who reached VGPR and PR. Likewise, addition of the new drugs bortezomib and thalidomide to standard chemotherapy led to considerably extended PFS and OS, compared with conventional therapy alone.CONCLUSIONS:
This analysis demonstrated that the quality of response after application of first-line treatment using novel agent-based regimens among multiple myeloma patients was a prognostic factor for PFS and OS, which are the most clinically relevant outcomes.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Mieloma Múltiple
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
País/Región como asunto:
Europa
Idioma:
Inglés
Revista:
São Paulo med. j
Asunto de la revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicina
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Año:
2022
Tipo del documento:
Artículo
Institución/País de afiliación:
University of Nis/RS
Similares
MEDLINE
...
LILACS
LIS