Expression of glycine receptor α3 subunit in neuropathic and inflammatory central pain sensitization
Rev. méd. Maule
;
34(2): 8-13, dic. 2019. tab
Artículo
en Inglés
| LILACS
| ID: biblio-1371186
ABSTRACT
INTRODUCTION:
Increasing evidence suggests that changes in the balance of excitatory/inhibitory neurotransmission are involved in the development of the majority of chronic pain forms. In this context, impairment in glycine mediated inhibitory neurotransmission is thought to play a critical role in the disinhibition that accounts for the development and maintenance of central pain hypersensitivity.AIMS:
The goal of this study was to evaluate the Glycine Receptor α3 subunit (α3GlyR) expression in neuropathic (Chronic Constriction Injury, CCI) and inflammatory (Zymosan A injected) animal models of chronic pain. RESULTS ANDCONCLUSION:
RT-qPCR analysis of spinal cord samples showed that glra3 gene expression does not change after 3 days of CCI and 4 hours of Zymosan A injection. However, we found that protein levels evaluated by Western blot increased after inflammatory pain. These data suggest that central sensitization is differentially regulated depending on the type of pain. α3GlyR protein expression plays an important role in the first step of inflammatory pain establishment.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Receptores de Glicina
/
Sensibilización del Sistema Nervioso Central
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Rev. méd. Maule
Asunto de la revista:
Medicina
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de Talca/CL
Similares
MEDLINE
...
LILACS
LIS