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Fibrous hamartoma of infancy with sarcomatous transformation: an unusual morphology
Kapatia, Gargi; Chatterjee, Debajyoti; Gupta, Kirti; Trehan, Amita.
  • Kapatia, Gargi; Post Graduate Institute of Medical Education & Research. Department of Histopathology. Chandigarh. IN
  • Chatterjee, Debajyoti; Post Graduate Institute of Medical Education & Research. Department of Histopathology. Chandigarh. IN
  • Gupta, Kirti; Post Graduate Institute of Medical Education & Research. Department of Histopathology. Chandigarh. IN
  • Trehan, Amita; Post Graduate Institute of Medical Education & Research. Department of Pediatrics. Chandigarh. IN
Autops. Case Rep ; 12: e2021380, 2022. graf
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1374490
ABSTRACT
ABSTRACT Background Fibrous hamartoma of infancy (FHI) is a rare soft tissue lesion arising as a subcutaneous mass involving the axilla, trunk, and upper arm in infants and children <2yrs. Sarcomatous transformation in FHI is described in anecdotal cases in the literature. Case Report We describe one such example arising as a mass in the lower back in a 3-month-old infant. On histology, the tumor contained classic triphasic morphology; however, brisk mitotic activity noted at multiple foci was diagnostically challenging to categorize. The tumor was evaluated for ETV6-NTRK3 fusion to exclude other common differentials. Conclusion While FHI may be frequently encountered in infants, rare sarcomatous transformation are known to occur and merits special attention as it can be misdiagnosed. Also, a close follow-up is warranted as the lesion is known to recur locally.


Texto completo: Disponible Índice: LILACS (Américas) Idioma: Inglés Revista: Autops. Case Rep Asunto de la revista: Anatomia / Patologia Cl¡nica / Patologia Legal Año: 2022 Tipo del documento: Artículo País de afiliación: India Institución/País de afiliación: Post Graduate Institute of Medical Education & Research/IN

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Texto completo: Disponible Índice: LILACS (Américas) Idioma: Inglés Revista: Autops. Case Rep Asunto de la revista: Anatomia / Patologia Cl¡nica / Patologia Legal Año: 2022 Tipo del documento: Artículo País de afiliación: India Institución/País de afiliación: Post Graduate Institute of Medical Education & Research/IN