The chemical composition and antibacterial activity of a methanolic extract of Satureja khuzistanica
Braz. J. Pharm. Sci. (Online)
;
58: e19233, 2022. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1374569
ABSTRACT
Abstract In the present study, the metabolite profiling of methanolic extract from aerial parts of Satureja khuzistanica Jamzad, as an endemic medicinal plant from Iran, was evaluated using HPLC-PDA-ESI. Then, the main compound from the extract was isolated and purified by using extensive chromatographic techniques. In addition, the structure of the isolated compounds was elucidated using 1D, 2D NMR, and MS spectrometry, upon which 22 compounds were identified. The antibacterial activity of diosmetin 7-rutinoside (6) and linarin (13) in combination with carvacrol as a major compound of the essential oil was tested against Pseudomonas aeruginosa and Staphylococcus aureus through disc diffusion and minimum inhibitory concentration methods. The results indicated that the linarin, when mixed with carvacrol as the main compounds in the essential oil of the plant, has a satisfactory activity against both Pseudomonas aeruginosa and Staphylococcus aureus with MIC values of 0.16 and 0.18 µg/mL, respectively. Further, the fractional inhibitory concentration (FIC) index indicated that this compound had synergism with carvacrol.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Plantas Medicinales
/
Aceites Volátiles
/
Lamiaceae
/
Satureja
Idioma:
Inglés
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
/
Teraputica
/
Toxicologia
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
Irán
Institución/País de afiliación:
Baqiyatallah University of Medical Sciences/IR
/
Islamic Azad University/IR
/
Shahid Beheshti University/IR
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