Your browser doesn't support javascript.
loading
Optimization of Diltiazem hydrochloride osmotic formulation using QBD approach
Joshi, Manjusha; Gokhale, Chinmay; Kenjale, Prathmesh; Pokharkar, Varsha.
  • Joshi, Manjusha; Bharati Vidyapeeth University. Poona College of Pharmacy. Department of Pharmaceutics. IN
  • Gokhale, Chinmay; Bharati Vidyapeeth University. Poona College of Pharmacy. Department of Pharmaceutics. IN
  • Kenjale, Prathmesh; Bharati Vidyapeeth University. Poona College of Pharmacy. Department of Pharmaceutics. IN
  • Pokharkar, Varsha; Bharati Vidyapeeth University. Poona College of Pharmacy. Department of Pharmaceutics. IN
Braz. J. Pharm. Sci. (Online) ; 58: e19779, 2022. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1383968
ABSTRACT
Abstract Diltiazem hydrochloride (DLH) is a calcium channel blocker useful for the treatment of angina pectoris, arrhythmia, and hypertension. DLH having a short half-life needs frequent administration for successful treatment but this poses a problem of poor patient compliance. These requirements are served by elementary osmotic pump tablets (EOP) based controlled-release (CR) systems. Quality by design (QbD) approach assists in screening various factors with subsequent assessment of critical parameters that can have a major impact on the scalability of EOP. Tablets were formulated using wet granulation method followed by osmotic coating. Factorial design based QbD strategy aided in defining the risk assessment of influential variables such as hydrophilic polymers and osmotic coat component on the in-vitro release kinetics of the designed EOP tablets. These formulated EOP systems followed zero-order kinetics, a characteristic feature of EOPs. EOP tablets were formulated applying a systematic QbD statistical approach. The formulated DLH EOP systems with improved concentration-independent behavior helped to address the challenges of IR formulation. Application of QbD strategy in ascertaining the scalability of DLH EOP formulation would help pharmaceutical industries in the translation of EOP based drug delivery systems from R&D to market.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Comprimidos / Diltiazem / Sistemas de Liberación de Medicamentos / Gestión de la Calidad Total / Métodos Tipo de estudio: Factores de riesgo Idioma: Inglés Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2022 Tipo del documento: Artículo País de afiliación: India Institución/País de afiliación: Bharati Vidyapeeth University/IN

Similares

MEDLINE

...
LILACS

LIS


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Comprimidos / Diltiazem / Sistemas de Liberación de Medicamentos / Gestión de la Calidad Total / Métodos Tipo de estudio: Factores de riesgo Idioma: Inglés Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2022 Tipo del documento: Artículo País de afiliación: India Institución/País de afiliación: Bharati Vidyapeeth University/IN