Challenging dilemmas of low grade, non-invasive bladder cancer: a narrative review
Int. braz. j. urol
;
48(3): 397-405, May-June 2022. tab, graf
Artículo
en Inglés
|
LILACS-Express
| LILACS
| ID: biblio-1385108
ABSTRACT
ABSTRACT Purpose: To describe the current scientific knowledge and clinical experience in low-grade-non-muscle-invasive bladder cancer (LG-NMIBC) patients in challenging scenarios. Materials and Methods: Medline, Embase, Google Scholar, and Cochrane Central were searched until March 2021. Results: A total of 841 studies were identified, and abstracts were analyzed. Twenty-one relevant studies were then identified and reviewed. After all, information was gathered from 16 studies, the authors discussed the specific topics, and expert opinions were also included in the discussion. There have been some studies that can help us to have some insights on how to manage these patients. Very distinctive strategies have been reported in the literature, mainly anecdotally or in small randomized studies. Some of these treatments outlined in the present manuscript include repeated TURBTs, chemoablation, BCG immunoablation, partial cystectomy, radical cystectomy, radiotherapy, chemotherapy, and future perspectives. In the current manuscript, we have combined these strategies in a proposed algorithm. Conclusion: For those LG-NMIBC patients in challenging scenarios, we have found repeated TURBTs, chemoablation, BCG immunoablation, partial cystectomy, radical cystectomy, radiotherapy, and chemotherapy are attractive modalities to treat them effectively. Also, the current manuscript proposes an algorithm to overcome these challenges.
Texto completo:
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Índice:
LILACS (Américas)
Tipo de estudio:
Ensayo Clínico Controlado
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Revisiones Sistemáticas Evaluadas
Idioma:
Inglés
Revista:
Int. braz. j. urol
Asunto de la revista:
Urología
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Colombia
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Italia
/
Estados Unidos
Institución/País de afiliación:
Faculdade de Medicina do ABC/BR
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H. Lee Moffitt Cancer Center and Research Institute/US
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Universidad Del Valle/CO
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University Vita-Salute San Raffaele/IT
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