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Hemorragia encefálica por angiopatía amiloidea / Amyloid angiopathy brain hemorrhage
Tapia, Jorge.
  • Tapia, Jorge; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Neurología. Santiago. CL
Rev. méd. Chile ; 149(1): 76-87, ene. 2021. tab, ilus
Artículo en Español | LILACS | ID: biblio-1389359
ABSTRACT
Amyloid angiopathy (AA) is a selective deposition of amyloid in the walls of the brain vessels. It is a form of sporadic and localized amyloidosis, constituted by the Aβ4 protein, the same of Alzheimer's disease senile plaques. The most consistent clinical effect of AA is spontaneous brain hemorrhage (BH). It is the second most common cause of BH after arterial hypertension (HT). Other clinical manifestations are cognitive impairment and transient focal neurological episodes. AA BH is characteristically localized in the cerebral cortex and subcortical white matter (lobar hemorrhage), consistent with the preferential deposit of amyloid in the walls of leptomeningeal and intracortical small cerebral vessels. Other types of AA hemorrhagic complications are microbleeds (MB), cerebral convexity subarachnoid hemorrhage (cSAH) and superficial hemosiderosis (cSS). The diagnosis of AA BH is based on the Boston criteria. Using these criteria, several non-hemorrhagic biomarkers of AA have been identified that can be useful in its diagnosis. The principal AA BH risk factor is age, followed by cSS, MB, Apolipoprotein E gen ε2 and ε4 alleles, HT and the use of antithrombotics. This condition has a high recurrence rate that shares the same risk factors. There is no specific treatment for AA BH. It has a better prognosis than HT BH during the acute period, but worse on the long term, due to its high recurrence rate and cognitive impairment.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Hemorragia Subaracnoidea / Angiopatía Amiloide Cerebral Tipo de estudio: Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Español Revista: Rev. méd. Chile Asunto de la revista: Medicina Año: 2021 Tipo del documento: Artículo País de afiliación: Chile Institución/País de afiliación: Pontificia Universidad Católica de Chile/CL

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Hemorragia Subaracnoidea / Angiopatía Amiloide Cerebral Tipo de estudio: Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Español Revista: Rev. méd. Chile Asunto de la revista: Medicina Año: 2021 Tipo del documento: Artículo País de afiliación: Chile Institución/País de afiliación: Pontificia Universidad Católica de Chile/CL