Anti-Snake Venom Properties of Medicinal Plants: A Comprehensive Systematic Review of Literature
Braz. J. Pharm. Sci. (Online)
;
58: e191124, 2022. tab
Artículo
en Inglés
| LILACS
| ID: biblio-1394054
ABSTRACT
Abstract Snakebite is one of the major health issues posing considerable morbidity and mortality. According to an estimate of World Health Organization (WHO) (World health organization, 2021) approximately 5 million people are bitten by several species of snakes resulting in up to 2.5 million envenomation cases annually. The mainstay of treatment for envenomation is intravenous administration of anti-snake venom. Although antivenom neutralizes the systemic effects but it does not relieve the symptoms such as venom-induced hemorrhage, necrosis and nephrotoxicity. Moreover, the use of antivenoms is associated with hypersensitivity reactions including urticaria, anaphylaxis, or serum sickness due to their heterologous property. Furthermore, stringent storage conditions and narrow specificity of antivenoms limit their use in both developed as well as developing countries. In this context, researchers have been searching for natural products and plant extracts to explore their antivenom activity along with anti-myotoxic, anti-hemorrhagic and anti-inflammatory properties. Plant remedies may prove to be an effective alternate for antivenom sera with less adverse events and better tolerability. To the best of our knowledge, this is the first comprehensive review of medicinal plants possessing anti-snake venom activities against certain species of snakes. The current review highlights the investigated plants with their phytochemical analysis to integrate the available information for future research and development of antivenom sera.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Plantas Medicinales
/
Venenos de Serpiente
/
Antivenenos
/
Venenos Elapídicos
/
Fitoquímicos
Tipo de estudio:
Revisiones Sistemáticas Evaluadas
Idioma:
Inglés
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
/
Teraputica
/
Toxicologia
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
Pakistán
/
Arabia Saudita
Institución/País de afiliación:
Jouf University/SA
/
Lahore College for Women University/PK
/
University College of Pharmacy/PK
/
University of Veterinary and Animal Sciences/PK
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