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Predictors of recurrence of peritoneal carcinomatosis among patients with colorectal cancer following cytoreductive surgery alone versus cytoreductive surgery plus HIPEC
Gareer, Waheed Yousry; Mohamed, Gamal Amira; Zedan, Mohamed H; Baradei, Tarek Sherif Al; Abdalgeleel, Shaimaa Abdalaleem; Khairallah, Sherif Mohamed.
  • Gareer, Waheed Yousry; Cairo University. National Cancer Institute. Department of Surgical Oncology. Cairo. EG
  • Mohamed, Gamal Amira; Cairo University. National Cancer Institute. Department of Surgical Oncology. Cairo. EG
  • Zedan, Mohamed H; Cairo University. National Cancer Institute. Department of Surgical Oncology. Cairo. EG
  • Baradei, Tarek Sherif Al; Cairo University. National Cancer Institute. Department of Surgical Oncology. Cairo. EG
  • Abdalgeleel, Shaimaa Abdalaleem; Cairo University. National Cancer Institute. Department of Epidemiology and Biostatistics. Cairo. EG
  • Khairallah, Sherif Mohamed; Cairo University. National Cancer Institute. Department of Surgical Oncology. Cairo. EG
J. coloproctol. (Rio J., Impr.) ; 42(2): 107-114, Apr.-June 2022. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1394411
ABSTRACT

Background:

Peritoneal carcinomatosis (PC) is a lethal regional progression in patients with colorectal cancer (CRC). Treatment with complete cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) achieves better local control than systemic palliative chemotherapy.

Objectives:

To assess the efficacy on the prognosis of CRS and HIPEC compared with CRS only and to identify possible clinicopathological factors associated with the recurrence of PC.

Methods:

The present retrospective study included all colorectal carcinoma cases with PC subjected to CRS with or without HIPC from January 2009 to June 2018 at the National Cancer Institute (NCI), Cairo University, Cairo, Egypt. The outcome is evaluated in terms of recurrence-free survival (RFS) and its predictors.

Results:

Out of the 61 patients, 45 patients (73.8%) underwent CRS plus HIPEC, and 16 (26.2%) underwent CRS alone. The 1-year RFS was 55.7%, with a median of 12 months. The risk factors for recurrence identified in the univariate analysis were T4 primary tumor, high-grade, positive lymphovascular invasion (LVI), positive extracapsular nodal spread, and patients treated with CRS only, without HIPEC. In the multivariate analysis, the independent risk factors for recurrence were high grade and patients treated with CRS only.

Conclusion:

T4 primary tumor, high grade, positive LVI, and positive extracapsular nodal spread seemed to be important predictors of recurrence following the treatment of PC. Our study also demonstrated that the addition of HIPEC to CRS improved the RFS. (AU)
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Neoplasias Peritoneales / Neoplasias Colorrectales / Procedimientos Quirúrgicos de Citorreducción Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: J. coloproctol. (Rio J., Impr.) Asunto de la revista: Cirurgia / Doen‡as Retais / Doen‡as do Colo / Gastroenterologia / Cirurgia Año: 2022 Tipo del documento: Artículo País de afiliación: Egipto Institución/País de afiliación: Cairo University/EG

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Neoplasias Peritoneales / Neoplasias Colorrectales / Procedimientos Quirúrgicos de Citorreducción Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: J. coloproctol. (Rio J., Impr.) Asunto de la revista: Cirurgia / Doen‡as Retais / Doen‡as do Colo / Gastroenterologia / Cirurgia Año: 2022 Tipo del documento: Artículo País de afiliación: Egipto Institución/País de afiliación: Cairo University/EG