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Central adrenal insufficiency: who, when, and how? From the evidence to the controversies - an exploratory review
Bitencourt, Mariana Rechia; Batista, Rafael Loch; Biscotto, Isabela; Carvalho, Luciani R..
  • Bitencourt, Mariana Rechia; Universidade São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Batista, Rafael Loch; Universidade São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Biscotto, Isabela; Saúde de Juiz de Fora. Faculdade de Ciências Médicas. Juiz de Fora. BR
  • Carvalho, Luciani R.; Universidade São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
Arch. endocrinol. metab. (Online) ; 66(4): 541-550, July-Aug. 2022. tab, graf
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1403229
ABSTRACT
ABSTRACT Central adrenal insufficiency (CAI) is a life-threatening disorder. This occurs when ACTH production is insufficient, leading to low cortisol levels. Since corticosteroids are crucial to many metabolic responses under organic stress and inflammatory conditions, CAI recognition and prompt treatment are vital. However, the diagnosis of CAI is challenging. This is not only because its clinical presentation is usually oligosymptomatic, but also because the CAI laboratory investigation presents many pitfalls. Thus, the clarification of when to use each test could be helpful in many contexts. The CAI challenge is also involved in treatment Several formulations of synthetic steroids exist, followed by the lack of a biomarker for glucocorticoid replacement. This review aims to access all available literature to synthesize important topics about who should investigate CAI, when it should be suspected, and how CAI must be treated.


Texto completo: Disponible Índice: LILACS (Américas) Idioma: Inglés Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: Endocrinologia / Metabolismo Año: 2022 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Saúde de Juiz de Fora/BR / Universidade São Paulo/BR

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Texto completo: Disponible Índice: LILACS (Américas) Idioma: Inglés Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: Endocrinologia / Metabolismo Año: 2022 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Saúde de Juiz de Fora/BR / Universidade São Paulo/BR