Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite
Braz. J. Pharm. Sci. (Online)
;
58: e20243, 2022. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1403682
ABSTRACT
Abstract In drug therapy, it is important to provide therapeutic levels of drug to the site of action and maintain them during the treatment. This work describes the in vitro release of alendronate from sodium alginate cross-linked Montmorillonite (MMT) composite beads. Effect of crosslinking cation, concentration of montmorillonite and media on encapsulation efficiencies, and release profiles of alendronate were studied. Beads were characterized using equilibrium swelling ability study, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Energy-dispersive x-ray spectroscopy (EDX) and scanning electron microscopy (SEM). Results indicate that addition of montmorillonite increases the encapsulation efficiencies and slows down the release rates significantly.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Bentonita
/
Alendronato
/
Alginatos
Idioma:
Inglés
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
/
Teraputica
/
Toxicologia
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
Irán
Institución/País de afiliación:
Islamic Azad University/IN
/
Islamic Azad University/IR
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