Formulation development of anti-rheumatoid gel of Saraca asoca (Roxb. ) De Wilde hydroalcoholic extract containing eucalyptus oil and peppermint oil as penetration enhancer
Braz. J. Pharm. Sci. (Online)
;
58: e20486, 2022. tab
Artículo
en Inglés
| LILACS
| ID: biblio-1403694
ABSTRACT
Abstract In the present research investigation, various concentrations of hydro-alcoholic extract of Saraca asoca (Roxb.) De Wilde (family Caesalpinaceae) dried bark and carbopol polymer at different temperature ranges were optimized for the preparation of gel formulation. Natural penetration enhancers, v.i.z., eucalyptus oil and peppermint oil were incorporated separately in the extract based gel formulations to study the rate of drug permeation across egg membrane, using franz diffusion cell. In vitro anti-arthritis potential of the formulations was also studied using inhibition of albumin denaturation, antiproteinase activity and membrane stabilization method. As per the results of current study, it is established that S. asoca dried bark hydroalcoholic extract based gel prepared using peppermint oil as penetration enhancer exhibited good permeation rate of 8.48% at the end of 3 h. The percentage inhibition of proteins by antiproteinase method at concentration of 50 µg/ml was 50.01±1.00% which was close to 53.92±0.99% as shown by the standard drug, Diclofenac. Also, the percent protein inhibition determined using membrane stabilization method was found to be 49.70±1.00%, however, it was 63.32±0.94% for the standard drug, Diclofenac. Hence, it is concluded that peppermint oil may act as a good candidate for the preparation of potent anti-rheumatic gel preparations.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Aceites de Plantas
/
Preparaciones Farmacéuticas
/
Joanesia asoca
/
Mentha piperita
/
Solución Hidroalcohólica
/
Aceite de Eucalipto
Idioma:
Inglés
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
/
Teraputica
/
Toxicologia
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
China
/
India
Institución/País de afiliación:
Center Hospital Affiliated to Shandong First Medical University/CN
/
Maharshi Dayanand University/IN
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