Clinical relevance of miR-423-5p levels in chronic obstructive pulmonary disease patients
Clinics
;
77: 100102, 2022. tab, graf
Artículo
en Inglés
|
LILACS-Express
| LILACS
| ID: biblio-1404291
ABSTRACT
Abstract Objective:
This study aimed to examine changes in miRNAs expression profile of COPD patients.Methods:
Thirty-six COPD patients as well as thirty-three healthy volunteers were recruited. Total RNAs were collected from the plasma of each participant. The differentially expressed miRNAs in COPD were screened from the GEO database. RT-qPCR was carried out to detect miRNA expression.Results:
In total, 9 out of 55 miRNAs were expressed differentially in COPD patients. Confirmed by RT-qPCR validation, 6 miRNAs increased while 3 miRNAs decreased. Further analysis of miR-423-5p, which has not been reported in COPD, showed that AUC for the diagnosis of COPD was 0.9651, and miR-423-5p levels was inversely correlated with the duration of smoking.Conclusion:
The present study demonstrates that miR-423-5p is a potential marker for identifying COPD patients.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2022
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
China
Institución/País de afiliación:
ChongQing TongLiang Peoples Hospital/CN
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