A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection
Rev. Soc. Bras. Med. Trop
;
55: e0239, 2022. tab, graf
Artículo
en Inglés
|
LILACS-Express
| LILACS
| ID: biblio-1406975
ABSTRACT
ABSTRACT Background:
The inflammatory response plays a significant role in the outcome of coronavirus disease (COVID-19).Methods:
We investigated plasma cytokine and chemokine concentrations in non-infected (NI), asymptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected blood donors (AS), and patients with severe COVID-19 (SC).Results:
The SC group showed significantly higher levels of interleukin 6 (IL-6), IL-10, and CCL5 than the AS and NI groups. The SC and AS groups had considerably greater CXCL9 and CXCL10 concentrations than the NI group. Only NI and infected people showed separate clusters in the principal component analysis.Conclusions:
SC, as well as AS was characterized by an inflammatory profile.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Fundação Centro de Hematologia e Hemoterapia de Minas Gerais/BR
/
Fundação Hospitalar do Estado de Minas Gerais/BR
/
Universidade Federal de Minas Gerais/BR
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