Clinical characteristics and factors associated with acute kidney injury among patients hospitalized with coronavirus disease: an observational retrospective study
São Paulo med. j
;
140(4): 566-573, July-Aug. 2022. tab, graf
Artículo
en Inglés
|
LILACS-Express
| LILACS
| ID: biblio-1410187
ABSTRACT
ABSTRACT BACKGROUND:
Coronavirus disease 19 (COVID-19) is a multisystemic disease with high incidence of acute kidney injury (AKI).OBJECTIVE:
To describe the clinical characteristics and factors associated with AKI among patients hospitalized with COVID-19. DESIGN ANDSETTING:
Retrospective cohort conducted at Hospital Civil de Culiacan, Mexico.METHODS:
We included 307 patients hospitalized due to COVID-19. AKI was defined and staged based on serum creatinine levels in accordance with the criteria of the Acute Kidney Injury Network (AKIN). Multivariate logistic regression analysis was used to determine factors associated with AKI.RESULTS:
The patients' age was 56 ± 15 years (64.5% male). The incidence of AKI was 33.6% (n = 103). Overall, 53.4% of patients had community-acquired AKI, and 46.6% had hospital-acquired AKI. Additionally, 15.5% of them presented AKIN stage 1; 34% had AKIN stage 2; and 50.5% had AKIN stage 3. Hemodialysis was required for 10.7% of the patients. The factors associated with AKI were chronic kidney disease (odds ratio, OR 10.8; P = 0.04), use of norepinephrine (OR 7.3; P = 0.002), diabetes mellitus (OR 2.9; P = 0.03), C-reactive protein level (OR 1.005; P = 0.01) and COVID-19 severity index based on chest tomography (OR 1.09; statistical trend, P = 0.07). Hospital stay (11 ± 7 days; P < 0.001) and mortality (83.5 versus 31.4%; P < 0.05) were greater among patients with AKI.CONCLUSION:
AKI was a frequent and serious complication in our cohort of patients hospitalized with COVID-19, which was associated with high mortality and long hospital stay.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Idioma:
Inglés
Revista:
São Paulo med. j
Asunto de la revista:
Cirurgia Geral
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Cincia
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Ginecologia
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Medicina
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Medicina Interna
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Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
México
Institución/País de afiliación:
Centro de Investigación y Docencia en Ciencias de la Salud/MX
/
Hospital Civil de Culiacán/MX
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