Clinical Characteristics and Survival Analysis in Frequent Alcohol Consumers With COVID-19
Front Nutr
;
8: 1-7, 2021.
Artículo
en Inglés
| LILACS, CONASS, ColecionaSUS, SES-SP, SESSP-IALPROD, SES-SP
| ID: biblio-1417260
ABSTRACT
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can generate a systemic disease named coronavirus disease2019 (COVID-19). Currently, the COVID-19 pandemic has killed millions worldwide, presenting huge health and economic challenges worldwide. Several risk factors, such as age, co-infections, metabolic syndrome, and smoking have been associated with poor disease progression and outcomes. Alcohol drinking is a common social practice among adults, but frequent and/or excessive consumption can mitigate the anti-viral and anti-bacterial immune responses. Therefore, we investigated if patients with self-reported daily alcohol consumption (DAC) presented alteration in the immune response to SARS-CoV-2. We investigated 122 patients with COVID-19 (101 male and 46 females), in which 23 were patients with DAC (18 men and 5 women) and 99 were non-DAC patients (58 men and 41 women), without other infections, neoplasia, or immunodeficiencies. Although with no difference in age, patients with DAC presented an increase in severity-associated COVID-19 markers such as C-reactive protein (CRP), neutrophil count, and neutrophil-to-lymphocyte ratio. In addition, patients with DAC presented a reduction in the lymphocytes and monocytes counts. Importantly, the DAC group presented an increase in death rate in comparison with the non-DAC group. Our results demonstrated that, in our cohort, DAC enhanced COVID-19-associated inflammation, and increased the number of deaths due to COVID-19.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Mujeres
/
Consumo de Bebidas Alcohólicas
/
Fumar
/
Análisis de Supervivencia
/
Mortalidad
/
Coronavirus
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Idioma:
Inglés
Revista:
Front Nutr
Año:
2021
Tipo del documento:
Artículo
Institución/País de afiliación:
Laboratorio de Dermatologia e Imunodeficiencias (LIM-56)/BR
/
Laboratorio de Dermatologia e Imunodeficiencias (LIM-56), Departamento de Dermatologia/BR
/
Laboratorio de Dermatologia e Imunodeficiencias (LIM-56)Departamento de Dermatologia/BR
/
Laboratorio de Dermatologia e Imunodeficiencias/BR
/
Technical Division of Medical Biology, Immunology Center, Adolfo Lutz Institute/BR
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