Surveillance of hemorrhagic fever and/or neuroinvasive disease: challenges of diagnosis
Rev Saude Publica
;
55(41): 1-10, 2021.
Artículo
en Inglés
| LILACS, CONASS, ColecionaSUS, SES-SP, SESSP-IALPROD, SES-SP
| ID: biblio-1418431
ABSTRACT
OBJECTIVE:
To evaluate the performance of post mortem laboratory analysis in identifying the causes of hemorrhagic fever and/or neuroinvasive disease in deaths by arbovirus infection.METHODS:
Retrospective cross-sectional study based on the differential analysis and final outcome obtained in patients whose samples underwent laboratory testing for arboviruses at the Pathology Center of the Adolfo Lutz Institute, in São Paulo, Brazil.RESULTS:
Of the 1355 adults clinically diagnosed with hemorrhagic fever and/or neuroinvasive disease, the most commonly attributed cause of death and the most common final outcome was dengue fever. Almost half of the samples tested negative on all laboratory tests conducted.CONCLUSION:
The failure to identify the causative agent in a great number of cases highlights a gap in the diagnosis of deaths of unknown etiology. Additional immunohistochemical and molecular assessments need to be added to the post-mortem protocol if all laboratory evaluations performed fail to identify a causative agent. While part of our findings may be due to technical issues related to sample fixation, better information availability when making the initial diagnosis is crucial. Including molecular approaches might lead to a significant advancement in diagnostic accuracy. DESCRIPTORS Autopsy. Hemorrhagic Fevers, Viral, etiology. Arbovirus Infections, mortality
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Infecciones por Arbovirus
/
Arbovirus
/
Autopsia
/
Estudios Transversales
/
Dengue
Tipo de estudio:
Estudio diagnóstico
/
Guía de Práctica Clínica
/
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
/
Estudio de tamizaje
Idioma:
Inglés
Revista:
Rev Saude Publica
Año:
2021
Tipo del documento:
Artículo
Institución/País de afiliación:
I Universidade de São Paulo. Instituto de Medicina Tropical/US
/
Instituto Adolfo Lutz/BR
/
Instituto Adolfo Lutz. Centro de Patologia/BR
/
Universidade de São Paulo/BR
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