Distractibility, anxiety, irritability, and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depression
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
44(6): 576-583, Nov.-Dec. 2022. tab, graf
Artículo
en Inglés
|
LILACS-Express
| LILACS
| ID: biblio-1420530
ABSTRACT
Objective:
To explore whether there is an association between distractibility, anxiety, irritability, and agitation (DAIA) symptoms and the severity of depressive and manic symptoms.Methods:
Patients with unipolar and bipolar disorder (I and II) and mixed depression were evaluated. DAIA symptoms were assessed using previously described definitions.Results:
The full analysis set comprised 100 patients. The severity of depressive symptoms in mixed depression, assessed by Montgomery-Åsberg Depression Rating Scale (MADRS), was significantly associated with the presence of two or more DAIA symptoms in the bipolar sample, influenced mainly by anxiety. The severity of manic symptoms in mixed depression, assessed by Young Mania Rating Scale (YMRS), was significantly associated with the presence of two or more DAIA symptoms in the bipolar sample and three or four DAIA symptoms in the unipolar sample.Conclusion:
DAIA symptoms were associated with greater severity of manic symptoms in mixed depression. DAIA symptoms must be evaluated in all patients with mixed features and are associated with the severity of depressive and manic symptoms in mixed depression. Clinical trial registration ClinicalTrials.gov (NCT04123301).
Texto completo:
Disponible
Índice:
LILACS (Américas)
Tipo de estudio:
Estudio diagnóstico
/
Factores de riesgo
Idioma:
Inglés
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Asunto de la revista:
Psiquiatria
Año:
2022
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
/
España
Institución/País de afiliación:
Instituto de Neurociencias, Universidad de Barcelona, LInstitut dInvestigacions Biomèdiques August Pi i Sunyer, Investigación Biomédica en Red en el Área de Salud Mental/ES
/
Instituto de Psiquiatria, Faculdade de Medicina, USP/BR
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Instituto de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo (USP)/BR
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