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Effect of protection of enoxaparin against experimental ischemia/reperfusion injury in the rat ovary on in vitro fertilization outcomes
Bostancı, Mehmet Suhha; Budak, Ozcan; Çakiroğlu, Hüseyin; Köse, Osman; Durmaz, Özkan; Cokluk, Erdem.
  • Bostancı, Mehmet Suhha; Sakarya Üniversitesi. Faculty of Medicine. Department of Obstetrics and Gynecology and Artificial Reproductive Techniques. Serdivan. TR
  • Budak, Ozcan; Sakarya Üniversitesi. Faculty of Medicine. Department of Histology and Embryology and Artificial Reproductive Techniques. Serdivan. TR
  • Çakiroğlu, Hüseyin; Sakarya Üniversitesi. Faculty of Medicine. Medical and Experimental Research Center. Serdivan. TR
  • Köse, Osman; Sakarya Üniversitesi. Faculty of Medicine. Department of Urology. Serdivan. TR
  • Durmaz, Özkan; Sakarya Üniversitesi. Faculty of Medicine. Department of Obstetrics and Gynecology. Serdivan. TR
  • Cokluk, Erdem; Sakarya Üniversitesi. Faculty of Medicine. Department of Biochemistry. Serdivan. TR
Rev. Assoc. Med. Bras. (1992, Impr.) ; 69(3): 380-385, Mar. 2023. graf
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1422651
ABSTRACT
SUMMARY

OBJECTIVE:

The study aimed to investigate the protection of enoxaparin (E) against experimental ischemic (I) and ischemic-reperfusion (I/R) injury in rat ovaries on in vitro fertilization outcomes.

METHODS:

In total, 56 adult female Sprague-Dawley albino rats were randomly assigned to 6 groups of 8 animals each Sham, Ischemia, I/R, Sham+E, I+E, and I/R+E. Ischemia groups were subjected to bilateral adnexal torsion for 3 h. In contrast, I/R and I/R+E groups received subsequent detorsion for 3 h. Enoxaparin (0.5 mg/kg s.c.) was administered 30 min prior to ischemia (I+platelet-rich plasma) or reperfusion (I/R+I+platelet-rich plasma). Ovaries were stimulated through intraperitoneal injection of 150-300 internal units IU/kg pregnant mare serum gonadotropin. Anti-Müllerian hormone levels were measured before and after surgery in all groups.

RESULTS:

When the number of metaphase II oocytes was evaluated, statistically significant differences were observed between the I and I+E (p=0.001) and I/R and I/R+E (p=0.000) groups. When both I and I+E groups and I/R and I/R+E groups were compared, it was found that E application increased the number of fertilized oocytes. The number of embryos on the second day was higher in the I/R+E group than that in the I/R group. Statistically significant differences were found in the number of grade 1 embryos between the I/R and I/R+E groups (p=0.003). In comparing anti-Müllerian hormone values within the group, the highest decrease was observed in the I and I/R groups.

CONCLUSION:

Enoxaparin effectively minimizes ovarian damage and preserves ovarian reserve following ovarian torsion.


Texto completo: Disponible Índice: LILACS (Américas) Idioma: Inglés Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Asunto de la revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / Medicina Año: 2023 Tipo del documento: Artículo País de afiliación: Turquía Institución/País de afiliación: Sakarya Üniversitesi/TR

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Texto completo: Disponible Índice: LILACS (Américas) Idioma: Inglés Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Asunto de la revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / Medicina Año: 2023 Tipo del documento: Artículo País de afiliación: Turquía Institución/País de afiliación: Sakarya Üniversitesi/TR