The triglyceride-glucose index as an indicator of insulin resistance and cardiometabolic risk in Brazilian adolescents
Arch. endocrinol. metab. (Online)
;
67(2): 153-161, 2023. tab
Artículo
en Inglés
|
LILACS-Express
| LILACS
| ID: biblio-1429732
ABSTRACT
ABSTRACT Objective:
To set cutoff points for the triglyceride and glucose index (TyG) as a marker of insulin resistance (IR) for the pediatric population. Subjects andmethods:
This was a cross-sectional study with schoolchildren population-based data using data of 377 schoolchildren age 10 to 17 years of both sexes. We studied metabolic variables associated with IR indicators, such as fasting insulin and blood glucose, to calculate the homeostatic model assessment (HOMA-IR), and we studied triglycerides (TG) to determine the TyG index. We obtained TyG cutoff values for IR using the receiver operation characteristic (ROC), with definitions of sensitivity (Sen), specificity (Spe), and area under the ROC curve (AUC), with the HOMA-IR as reference.Results:
The cutoff points of the TyG index for IR in adolescents are 7.94 for both sexes, 7.91 for boys, and 7.94 for girls, indicating moderate discriminatory power. When we also considered anthropometric variables of excess weight [TyG-BMI (body mass index)] and visceral fat [TyG-WC (waist circumference)], these indexes reached AUC values higher than 0.72, enhancing their potential use for a good diagnosis.Conclusion:
TyG has proven to be a useful instrument for identifying IR in adolescent health screening, with high discrimination capacity when added to anthropometric variables, making it a feasible and inexpensive option.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
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Factores de riesgo
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Arch. endocrinol. metab. (Online)
Asunto de la revista:
Endocrinologia
/
Metabolismo
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal de São Carlos/BR
/
Universidade Federal do Rio Grande do Sul/BR
/
Universidade de Santa Cruz do Sul/BR
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