Hemophilia: a biography on therapeutical approaches
Clin. biomed. res
;
43(1): 69-74, 2023.
Artículo
en Inglés
| LILACS
| ID: biblio-1435967
ABSTRACT
The history of hemophilia is ancient, with descriptions dated to the 2nd century AD. The first modern narratives appeared in 1800s, when total blood transfusion was the only available treatment and life expectancy was remarkably low. Advances occurred with the use of plasma and cryoprecipitate, but only the discovered of factor concentrates revolutionized the treatment. The implantation of prophylaxis allowed hemophilic patients to prevent bleeding and the development of chronic arthropathy, although with a significant burdensome with the regular infusions. In the past 20 years, this field has witnessed major improvements, including the development of gene therapy and other pharmacological approaches.
Asunto(s)
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Factor IX
/
Factor VIII
/
Hemofilia B
/
Hemofilia A
Límite:
Humanos
Idioma:
Inglés
Revista:
Clin. biomed. res
Asunto de la revista:
Medicina
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Hospital de Clínicas de Porto Alegre/BR
/
Universidade Estadual do Rio Grande do Sul/BR
/
Universidade Federal do Rio Grande do Sul/BR
/
Universidade de Caxias do Sul/BR
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