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Long-term effects of ayahuasca in patients with recurrent depression: a 5-year qualitative follow-up
Santos, Rafael G. dos; Sanches, Rafael Faria; Osório, Flávia de Lima; Hallak, Jaime E. C.
  • Santos, Rafael G. dos; University of São Paulo. Ribeirão Preto Medical School. Department of Neurosciences and Behavior. Ribeirão Preto. BR
  • Sanches, Rafael Faria; University of São Paulo. Ribeirão Preto Medical School. Department of Neurosciences and Behavior. Ribeirão Preto. BR
  • Osório, Flávia de Lima; University of São Paulo. Ribeirão Preto Medical School. Department of Neurosciences and Behavior. Ribeirão Preto. BR
  • Hallak, Jaime E. C; University of São Paulo. Ribeirão Preto Medical School. Department of Neurosciences and Behavior. Ribeirão Preto. BR
Rev. psiquiatr. clín. (São Paulo) ; 45(1): 22-24, Jan.-Feb. 2018. tab
Artículo en Inglés | LILACS | ID: biblio-1438577
ABSTRACT
Background Ayahuasca is a botanical hallucinogenic preparation traditionally used by indigenous populations of Northwestern Amazonian countries for ritual and therapeutic purposes. It is rich in β-carboline alkaloids and N,N-dimethyltryptamine (DMT). Preclinical, observational, and experimental studies suggest that ayahuasca and its alkaloids have anxiolytic and antidepressive effects. We recently reported in an open-label trial that ayahuasca administration was associated with significant decreases in depression symptoms for 2-3 weeks after the experimental session in 17 patients with treatment-resistant major depressive disorder. Objectives To investigate if the experiment had any long-lasting effects on patients Methods Eight patients were interviewed 4 to 7 years after ayahuasca intake. Results Our results suggest that ayahuasca was well tolerated and that symptom reductions were limited to a few weeks. Importantly, most patients believed that the experience was among the most important of their lives, even 4-7 years later. Discussion To the best of our knowledge, this is the first long-term follow-up of a clinical sample that participated in an ayahuasca trial. Further studies with different and repeated dosing should be designed to further explore the antidepressive and anxiolytic effects of ayahuasca.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Banisteriopsis / Depresión Tipo de estudio: Estudio observacional / Estudio pronóstico / Investigación cualitativa / Factores de riesgo Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Rev. psiquiatr. clín. (São Paulo) Año: 2018 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: University of São Paulo/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Banisteriopsis / Depresión Tipo de estudio: Estudio observacional / Estudio pronóstico / Investigación cualitativa / Factores de riesgo Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Rev. psiquiatr. clín. (São Paulo) Año: 2018 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: University of São Paulo/BR