Histopathological, ultrastructural, and immunohistochemical examination of changes in the placenta as a result of severe preeclampsia
Acta cir. bras
;
38: e382023, 2023. tab, ilus
Artículo
en Inglés
| LILACS, VETINDEX
| ID: biblio-1439112
ABSTRACT
Purpose:
To investigate the role of hypoxia-inducible transcription factor-1 alpha (HIF-1α) and angiogenetic factor endothelin-1 (ET-1) expression in regulating hypoxia and placental development by routine histopathological methods.Methods:
Twenty preeclamptic and normal placentas were used. Placenta tissue pieces were examined histopathologically after routine paraffin follow-ups. HIF-1α and ET-1 proteins were examined immunohistochemically, and placental tissues were examined ultrastructurally.Results:
Increase in syncytial proliferation, endothelial damage in vessels, and increase in collagen were observed in preeclamptic placentas. As a result of preeclampsia, an increase was observed in HIF-1α and ET-1 protein levels in the placenta. Dilatation of endoplasmic reticulum and loss of cristae in mitochondria were observed in trophoblast cells in preeclamptic placental sections.Conclusion:
High regulation of oxygen resulting from preeclampsia has been shown to be a critical determinant of placentagenesis and plays an important role in placental differentiation, changes in maternal and fetal blood circulation, trophoblastic invasion, and syncytial node increase. It has been thought that preeclampsia affects secretion by disrupting the endoplasmic reticulum structure and induces mitochondrial damage, and that ET-1 may potentially help in the induction of stress pathways as a result of hypoxia in preeclampsia.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Placenta
/
Enfermedades Placentarias
/
Preeclampsia
/
Endotelinas
/
Subunidad alfa del Factor 1 Inducible por Hipoxia
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Dicle University/TR
/
Harran University/TR
/
Zeynep Kâmil Hospital/TR
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