Curcumin alleviated oxidation stress injury by mediating osteopontin in nephrolithiasis rats
Acta cir. bras
;
38: e380223, 2023. graf, ilus
Artículo
en Inglés
| LILACS, VETINDEX
| ID: biblio-1439114
ABSTRACT
Purpose:
To explore the role and mechanism of curcumin (Cur) in reducing oxidative stress damage in rats with nephrolithiasis induced by ethylene glycol (EG).Methods:
Thirty male rats were divided into normal control, model, positive (10% potassium citrate), Cur-10 (10 mg/kg curcumin) and Cur-20 (20 mg/kg curcumin) groups.Results:
The results of kidney tissue section stained by hematoxylin-eosin and von Kossa showed that curcumin treatment can inhibit the formation of kidney stones. The biochemical test results showed that the urea (Ur), creatinine (Cr), uric acid (UA), inorganic phosphorus and Ca2+ concentrations in urine decreased after being treated with curcumin. There were significant differences between different doses of curcumin (P < 0.05). Compared with the Cur-10 group, Cur-20 had a more significant inhibitory effect on malondialdehyde (MDA) (P < 0.05). In addition, reverse transcription polymerase chain reaction (PCR) detection and immunohistochemical results indicated that the osteopontin (OPN) in the kidney was significantly reduced after curcumin treatment.Conclusion:
Curcumin could reduce the oxidative stress damage caused by EG-induced kidney stones.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Estrés Oxidativo
/
Glicol de Etileno
/
Curcumina
/
Osteopontina
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Año:
2023
Tipo del documento:
Artículo
Institución/País de afiliación:
Ningbo University/CN
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