Cyanidin-3-O-glucoside plays a protective role against renal ischemia/ reperfusion injury via the JAK/STAT pathway
Acta cir. bras
;
38: e381023, 2023. ilus, graf
Artículo
en Inglés
| LILACS, VETINDEX
| ID: biblio-1439116
ABSTRACT
Purpose:
To investigate the role of cyanidin-3-O-glucoside (C3G) in renal ischemia/reperfusion (I/R) injury and the potential mechanisms.Methods:
Mouse models were established by clamping the left renal vessels, and in vitro cellular models were established by hypoxic reoxygenation.Results:
Renal dysfunction and tissue structural damage were significantly higher in the I/R group. After treatment with different concentrations of C3G, the levels of renal dysfunction and tissue structural damage decreased at different levels. And its protective effect was most pronounced at 200 mg/kg. The use of C3G reduced apoptosis as well as the expression of endoplasmic reticulum stress (ERS)-related proteins. Hypoxia/reoxygenation (H/R)-induced apoptosis and ERS are dependent on oxidative stress in vitro. In addition, both AG490 and C3G inhibited the activation of JAK/STAT pathway and attenuated oxidative stress, ischemia-induced apoptosis and ERS.Conclusions:
The results demonstrated that C3G blocked renal apoptosis and ERS protein expression by preventing reactive oxygen species (ROS) production after I/R via the JAK/STAT pathway, suggesting that C3G may be a potential therapeutic agent for renal I/R injury.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Daño por Reperfusión
/
Sistema de Señalización de MAP Quinasas
/
Quinasas Janus
/
Lesión Renal Aguda
/
Isquemia
/
Antocianinas
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Año:
2023
Tipo del documento:
Artículo
Institución/País de afiliación:
Renmin Hospital of Wuhan University/CN
/
University of Science and Technology of China/CN
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