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Repetitive transcranial magnetic stimulation for treatment of limb spasticity following multiple sclerosis: a systematic review and meta-analysis
Su, Dongyun; Wang, Anzi; Zhu, Meirong; Yang, Fei; Li, Wei; Ma, Bo; Liu, Min; Li, Zongqi; Wang, Bo; Tu, Huanyi; Ning, Bo.
  • Su, Dongyun; The First Peoples Hospital of Longquanyi District Chengdu. Department of Neurology. Longquanyi District. CN
  • Wang, Anzi; The Third Peoples Hospital of Chengdu. Department of Hematology. Qingyang District. CN
  • Zhu, Meirong; The First Peoples Hospital of Longquanyi District Chengdu. Department of Neurology. Longquanyi District. CN
  • Yang, Fei; The First Peoples Hospital of Longquanyi District Chengdu. Department of Neurology. Longquanyi District. CN
  • Li, Wei; The First Peoples Hospital of Longquanyi District Chengdu. Department of Neurology. Longquanyi District. CN
  • Ma, Bo; The First Peoples Hospital of Longquanyi District Chengdu. Department of Neurology. Longquanyi District. CN
  • Liu, Min; The First Peoples Hospital of Longquanyi District Chengdu. Department of Neurology. Longquanyi District. CN
  • Li, Zongqi; The First Peoples Hospital of Longquanyi District Chengdu. Department of Neurology. Longquanyi District. CN
  • Wang, Bo; The First Peoples Hospital of Longquanyi District Chengdu. Department of Neurology. Longquanyi District. CN
  • Tu, Huanyi; The First Peoples Hospital of Longquanyi District Chengdu. Department of Neurology. Longquanyi District. CN
  • Ning, Bo; The First Peoples Hospital of Longquanyi District Chengdu. Department of Neurology. Longquanyi District. CN
Braz. j. med. biol. res ; 56: e12708, 2023. tab, graf
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1439706
ABSTRACT
Pilot trials have suggested that repetitive transcranial magnetic stimulation (rTMS) may reduce limb spasticity in multiple sclerosis (MS). We carried out the current meta-analysis to synthesize currently available evidence regarding such correlation. Up to November 2022, five international electronic databases (Cochrane CENTRAL, PubMed, Embase, Web of Science, and CINAHL) and four Chinese electronic databases (CBM, CNKI, WanFang Data, and VIP) were systematically searched to identify randomized trials comparing active rTMS and sham stimulation in patients with MS-related spasticity. Two reviewers independently selected studies and extracted data on study design, quality, clinical outcomes, and time points measured. The primary outcome was clinical spasticity relief after intervention. Secondary outcomes included spasticity at the follow-up visit 2 weeks later and post-treatment fatigue. Of 831 titles found, we included 8 studies (181 participants) in the quantitative analysis. Pooled analyses showed that rTMS therapy was associated with significant spasticity relief in the early post-intervention period [standardized mean differences (SMD) -0.67; 95%CI -1.12 to -0.21], but there was insufficient evidence for rTMS in reducing spasticity at the follow-up visit 2 weeks later (SMD -0.17; 95%CI -0.52 to 0.17) and fatigue (SMD -0.26; 95%CI -0.84 to 0.31). This evidence supports the recommendations to treat MS-related spasticity with rTMS, but underlines the need for further large randomized trials.


Texto completo: Disponible Índice: LILACS (Américas) Tipo de estudio: Ensayo Clínico Controlado / Guía de Práctica Clínica / Revisiones Sistemáticas Evaluadas Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2023 Tipo del documento: Artículo País de afiliación: China Institución/País de afiliación: The First Peoples Hospital of Longquanyi District Chengdu/CN / The Third Peoples Hospital of Chengdu/CN

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Texto completo: Disponible Índice: LILACS (Américas) Tipo de estudio: Ensayo Clínico Controlado / Guía de Práctica Clínica / Revisiones Sistemáticas Evaluadas Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2023 Tipo del documento: Artículo País de afiliación: China Institución/País de afiliación: The First Peoples Hospital of Longquanyi District Chengdu/CN / The Third Peoples Hospital of Chengdu/CN