Amplifications of AURKA and AURKB in a Burkitt lymphoma immunodeficiency-associated type: a case report
Einstein (Säo Paulo)
; 21: eRC0378, 2023. graf
Article
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LILACS-Express
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| ID: biblio-1448182
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BR1.1
ABSTRACT
ABSTRACT In equatorial Brazil, the association of Burkitt lymphoma and Epstein-Barr virus manifests at high rates. Here, we report, for the first time, amplifications of aurora kinase genes (AURKA/B) in a patient with a history of periodontal abscess and the presence of a remaining nodule, diagnosed with Burkitt lymphoma and Epstein-Barr virus, and /HIV positive. The patient was a 38-year-old man who presented with a 2-week-old severe jaw pain and a 3-day-old severe bilateral headache. He had a history of human papilloma virus. Interphase FISH analysis showed AURKA and AURKB amplification. The patient's condition worsened, progressing to death a month after the initial care. Changes in the MYCC and AURKA pathways are directly associated with genomic instability. Thus, MYCC rearrangements and higher expression of AURKA/B may be associated with therapy resistance, highlighting the importance of AURKA/B evaluation in Burkitt lymphoma.
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LILACS
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Einstein (Säo Paulo)
Asunto de la revista:
MEDICINA
Año:
2023
Tipo del documento:
Article