In vivo and in vitro prospection of the anti-ophidic properties exercised by the extracts of Jacaranda decurrens L
Acta sci., Biol. sci
;
43: e57016, 2021. tab, graf
Artículo
en Inglés
| LILACS, VETINDEX
| ID: biblio-1461014
ABSTRACT
The research and development of alternative treatments for snakebites (e.g., medicinal plants) is necessary due to the high costs of the existing ones. The effects of the aqueous extracts from Jacaranda decurrens leaves, roots, and xylopodium were analyzed upon the venom-induced (Bothrops spp. and Crotalus spp.) systemic and local toxicity. The extracts were able to partially inhibit the phospholipase activity of the venoms from Bothrops jararacussu and Crotalus durissus terrificus. The myotoxic, edema-inducing, coagulant, and hemorrhagic activities were also inhibited. The SDS-PAGE showed that the venom proteins were intact after their incubation with the extracts. This suggests that the possible mechanism of inhibition is not related to the degradation of the protein but rather to their binding to specific sites of the enzymes. The extracts significantly prolonged the survival time of animals in the lethality assay performed with Crotalus durissus terrificus venom and its toxin (crotoxin). The anti-ophidic activity of medicinal plants may aid in the management of snakebites in distant locations by reducing the victims local effects and time to heal.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Plantas Medicinales
/
Técnicas In Vitro
/
Venenos de Crotálidos
/
Bignoniaceae
Idioma:
Inglés
Revista:
Acta sci., Biol. sci
Año:
2021
Tipo del documento:
Artículo
Institución/País de afiliación:
Fundação Oswaldo Cruz/BR
/
Universidade Federal de Lavras/BR
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