Molecular cloning of a hyaluronidase from Bothrops pauloensis venom gland
J. venom. anim. toxins incl. trop. dis
;
20: 1-9, 04/02/2014. ilus
Artículo
en Inglés
| LILACS, VETINDEX
| ID: biblio-1484576
ABSTRACT
Hyaluronate is one of the major components of extracellular matrix from vertebrates whose breakdown is catalyzed by the enzyme hyaluronidase. These enzymes are widely described in snake venoms, in which they facilitate the spreading of the main toxins in the victims body during the envenoming. Snake venoms also present some variants (hyaluronidases-like substances) that are probably originated by alternative splicing, even though their relevance in envenomation is still under investigation. Hyaluronidases-like proteins have not yet been purified from any snake venom, but the cDNA that encodes these toxins was already identified in snake venom glands by transcriptomic analysis. Herein, we report the cloning and in silico analysis of the first hyaluronidase-like proteins from a Brazilian snake venom.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Venenos de Víboras
/
Clonación Molecular
/
Hialuronoglucosaminidasa
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
J. venom. anim. toxins incl. trop. dis
Año:
2014
Tipo del documento:
Artículo
Institución/País de afiliación:
Universidade Federal de Uberlândia/BR
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