Hepatotoxicity and oxidative stress induced by Naja haje crude venom
J. venom. anim. toxins incl. trop. dis
;
20: 1-10, 04/02/2014. tab, ilus
Artículo
en Inglés
| LILACS, VETINDEX
| ID: biblio-1484587
ABSTRACT
Snake venoms are synthesized and stored in venom glands. Most venoms are complex mixtures of several proteins, peptides, enzymes, toxins and non-protein components. In the present study, we investigated the oxidative stress and apoptosis in rat liver cells provoked by Naja haje crude injection (LD50) after four hours. Wistar rats were randomly divided into two groups, the control group was intraperitoneally injected with saline solution while LD50-dose envenomed group was intraperitoneally injected with venom at a dose of 0.025 μg/kg of body weight. Animals were killed four hours after the injection. Lipid peroxidation, nitric oxide and glutathione levels were measured as oxidative markers in serum and liver homogenate. In addition, liver function parameters and activities of antioxidant enzymes were determined.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Ratas
/
Venenos de Serpiente
/
Apoptosis
/
Estrés Oxidativo
Límite:
Animales
Idioma:
Inglés
Revista:
J. venom. anim. toxins incl. trop. dis
Año:
2014
Tipo del documento:
Artículo
Institución/País de afiliación:
King Saud University/SA
/
University of Oviedo/ES
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