Tissue apoptosis in mice infected with Leptospira interrogans serovar Icterohaemorrhagiae
J. venom. anim. toxins incl. trop. dis
;
21: 1-6, 31/03/2015. ilus, graf
Artículo
en Inglés
| LILACS, VETINDEX
| ID: biblio-1484626
ABSTRACT
Background:
This investigation aimed to evaluate the occurrence of some apoptotic features induced by Leptospira interrogans serovar Icterohaemorrhagiae infection in young BALB/c mice during 2, 4, 7, 10, 14 and 21 days post-infection (dpi).Methods:
The animals were euthanized and lung, liver and kidneys were harvested to histopathology analysis and immunohistochemistry to caspase-3 antigen detection was performed.Results:
Chromatin condensation in kidney and liver tissues, but not in lung tissue, was observed. Caspase-3 reactive cells, mainly characterized as renal epithelial cells, were detected in the days 14 and 21 at high levels when compared to days 2,4 and 7 (p = 0.025; p <0.05). Lung sections revealed caspase-3 labeled alveolar cells in 10 and 14 days post-infection was higher than observed at 7 days (p = 0.0497; p < 0.05). Liver sections demonstrated reactive cells at a highest level at 14 and 21 days post-infection when comparison to 2,4, 7 and 10 days (p = 0.0069; p<0.05).Conclusions:
Our results suggest that infection of L interrogans induce in kidney, liver and lung an activation of apoptosis mediated by caspase-3 dependent pathway in later phases of infectious process.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Enfermedad de Weil
/
Apoptosis
/
Leptospira interrogans serovar icterohaemorrhagiae
Límite:
Animales
Idioma:
Inglés
Revista:
J. venom. anim. toxins incl. trop. dis
Año:
2015
Tipo del documento:
Artículo
/
Documento de proyecto
Institución/País de afiliación:
São Paulo State University/BR
/
Universidade Federal de São Paulo/BR
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